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Article

Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes.

Journal of lipid research - 1 Sept 2010

Su Zhiguang, Leduc Magalie S, Korstanje Ron, Paigen Beverly

Abstract excerpt

Two high-density lipoprotein cholesterol quantitative trait loci (QTL), Hdlq1 at 125 Mb and Hdlq8 at 113 Mb, were previously identified on mouse distal chromosome 5. Our objective was to identify the underlying genes. We first used bioinformatics to narrow the Hdlq1 locus to 56 genes. The most likely candidate, Scarb1 (scavenger receptor B1), was supported by gene expression data consistent with knockout and...

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Share to Acyl-CoA Dehydrogenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Crosses, Genetic

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Share to Mice, Inbred BALB C

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Share to Scavenger Receptors, Class B

Source

Open in PubMed Open full text

Identifiers

PMID: 20562441
DOI: 10.1194/jlr.M008110
PMCID: PMC2918452

Genes

ACADS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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