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Article

Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci.

Genome research - 1 Jul 2003

Wang Xiaosong, Le Roy Isabelle, Nicodeme Edwige, Li Renhua, Wagner Richard, Petros Christina, Churchill Gary A, Harris Stephen, Darvasi Ariel, Kirilovsky Jorge, Roubertoux Pierre L, Paigen Beverly

Abstract excerpt

Mapping quantitative trait loci (QTLs) with high resolution facilitates identification and positional cloning of the underlying genes. The novel approach of advanced intercross lines (AILs) generates many more recombination events and thus can potentially narrow QTLs significantly more than do conventional backcrosses and F2 intercrosses. In this study, we carried out QTL analyses in (C57BL/6J x NZB/BlNJ) x...

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Identifiers

PMID: 12805272
DOI: 10.1101/gr.1185803
PMCID: PMC403739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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