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Article

BMP Pathway Regulation of and by Macrophages

8 Apr 2014

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a disease of progressively increasing pulmonary vascular resistance, associated with mutations of the type 2 receptor for the BMP pathway, BMPR2. The canonical signaling pathway for BMPR2 is through the SMAD family of transcription factors. BMPR2 is expressed in every cell type, but the impact of BMPR2 mutations affecting SMAD signaling, such as Bmpr2delx4+, had only...

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PMID: 24713633
DOI: 10.1371/journal.pone.0094119

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