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Article

Dose-dependent association between UGT1A1*28 genotype and irinotecan-induced neutropenia: low doses also increase risk.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2010

Hu Zhe-Yi, Yu Qi, Pei Qi, Guo Cheng

Abstract excerpt

PURPOSE: A previous meta-analysis showed that the association between the UGT1A1*28 genotype and irinotecan-induced neutropenia was influenced by irinotecan dose and that the risk of neutropenia was similar at low doses for patients with all genotypes. However, the sample sizes for the low- and high-dose groups were small. Because additional studies have now been reported, an updated and refined meta-analysis is...

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Source

Identifiers

PMID: 20562211
DOI: 10.1158/1078-0432.CCR-10-1122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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