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Article

Associations between UGT1A16 or UGT1A16/*28 polymorphisms and irinotecan-induced neutropenia in Asian cancer patients.

Cancer chemotherapy and pharmacology - 1 Apr 2014

Han Fei-fei, Guo Chang-long, Yu Dan, Zhu Jin, Gong Li-li, Li Guang-run, Lv Ya-li, Liu He, An Guang-yu, Liu Li-hong

Abstract excerpt

PURPOSE: Neutropenia is a life-threatening side effect of irinotecan, and uridine diphosphate glucuronosyltransferases (UGTs) gene polymorphisms are considered to be one of the predictive markers of irinotecan-related toxicities. Many studies have demonstrated that patients bearing UGT1A1*28 have a higher risk of severe neutropenia on toxicity of irinotecan. However, UGT1A1 (TA7/TA7) was very rare in Asian...

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PMID: 24519753
DOI: 10.1007/s00280-014-2405-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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