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Article

The association of UGT1A16 and UGT1A128 with irinotecan-induced neutropenia in Asians: a meta-analysis.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Feb 2014

Chen Yi-Jing, Hu Fei, Li Chun-Yan, Fang Jue-Min, Chu Li, Zhang Xi, Xu Qing

Abstract excerpt

BACKGROUND: The UGT1A1*28 polymorphism is known as a biomarker of irinotecan-induced neutropenia in Caucasians. However, in Asians, the UGT1A1*28 mutation is much less frequent. METHODS: A meta-analysis was performed to assess the association of the UGT1A1*6 and UGT1A1*28 with neutropenia in Asians. RESULTS: In a combination test of the two variations, patients with severe neutropenia displayed a 155% higher...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24308720
DOI: 10.3109/1354750X.2013.867534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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