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Article

Irinotecan-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.

The pharmacogenomics journal - 1 Jan 2017

Campbell J M, Stephenson M D, Bateman E, Peters M D J, Keefe D M, Bowen J M

Abstract excerpt

Irinotecan chemotherapy toxicities can be severe, and may result in treatment delay, morbidity and in some rare cases death. This systematic review of systematic reviews synthesises all meta-analyses on biomarkers for irinotecan toxicity across all genetic models for Asians, Caucasians, low dose, medium/high dose and regimens with and without fluorouracil. False-positive findings are a problem in...

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Identifiers

PMID: 27503581
DOI: 10.1038/tpj.2016.58

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