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Article

UGT1A1*6 polymorphisms are correlated with irinotecan-induced neutropenia: a systematic review and meta-analysis.

Cancer chemotherapy and pharmacology - 1 Jul 2017

Zhang Xue, Yin Jia-Fu, Zhang Jiao, Kong Shu-Jia, Zhang Hong-Yin, Chen Xue-Mei

Abstract excerpt

Irinotecan (IRI) chemotherapy toxicities can be severe, and may result in treatment delay, morbidity and in some rare cases death. Neutropenia is a life-threatening side effect of irinotecan, and UDP glucuronosyltransferases (UGTs) gene polymorphisms could predict the side effects in cancer patients and then reduce IRI-induced toxicity by preventative treatment or a decrease in dose. Both UGT1A1*6 and *28 were...

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PMID: 28585035
DOI: 10.1007/s00280-017-3344-3

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