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Article

Clinical observations on associations between the UGT1A1 genotype and severe toxicity of irinotecan.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Lu Yan-Yan, Huang Xin-En, Wu Xue-Yan, Cao Jie, Liu Jin, Wang Lin, Xiang Jin

Abstract excerpt

BACKGROUND: Severe toxicity is commonly observed in cancer patients receiving irinotecan (CPT-11). UDP glucuronosyltransferase1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38 but the relationship between UGT1A1 and severe toxicity remains unclear. Our study aimed to assess this point to guide clinical use of CPT-11. MATERIALS AND METHODS: 89 cancer patients with advanced disease received...

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Source

Identifiers

PMID: 24815493
DOI: 10.7314/apjcp.2014.15.7.3335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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