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Article

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Apr 2004

Innocenti Federico, Undevia Samir D, Iyer Lalitha, Chen Pei Xian, Das Soma, Kocherginsky Masha, Karrison Theodore, Janisch Linda, Ramírez Jacqueline, Rudin Charles M, Vokes Everett E, Ratain Mark J

Abstract excerpt

PURPOSE: Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38. This study prospectively evaluated the association between the prevalence of severe toxicity and UGT1A1 genetic variation. PATIENTS AND METHODS: Sixty-six cancer patients with advanced disease refractory to other treatments...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15007088
DOI: 10.1200/JCO.2004.07.173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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