Article
Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing.
Neuro-oncology - 1 Jun 2013
Agarwal Shipra, Sharma Mehar Chand, Jha Prerana, Pathak Pankaj, Suri Vaishali, Sarkar Chitra, Chosdol Kunzang, Suri Ashish, Kale Shashank Sharad, Mahapatra Ashok Kumar, Jha Pankaj
Abstract excerpt
BACKGROUND: Mutations involving isocitrate dehydrogenase 1 (IDH 1) occur in a high proportion of diffuse gliomas, with implications on diagnosis and prognosis. About 90% involve exon 4 at codon 132, replacing amino acid arginine with histidine (R132H). Rarer ones include R132C, R132S, R132G, R132L, R132V, and R132P. Most authors have used DNA-based methods to assess IDH1 status. Preliminary studies comparing...
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