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Article

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2009

Sanson Marc, Marie Yannick, Paris Sophie, Idbaih Ahmed, Laffaire Julien, Ducray François, El Hallani Soufiane, Boisselier Blandine, Mokhtari Karima, Hoang-Xuan Khe, Delattre Jean-Yves

Abstract excerpt

PURPOSE: Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of glioblastomas. PATIENTS AND METHODS: IDH1 codon 132 sequencing was performed in a series of 404 patients with glioma (100 grade 2, 121 grade 3, and 183 grade 4 gliomas) and correlated with histology, genomic profile, methylguanyl methyltransferase (MGMT) promoter methylation status, and outcome....

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Share to Disease-Free Survival
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Gene Expression Regulation, Enzymologic

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Share to Isocitrate Dehydrogenase

Share to Kaplan-Meier Estimate

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Source

Identifiers

PMID: 19636000
DOI: 10.1200/JCO.2009.21.9832

Genes

IDH1
MGMT
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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