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Article

Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.

PloS one - 14 Jun 2010

Ryan Gavin J, Hoff Donald R, Driver Emily R, Voskuil Martin I, Gonzalez-Juarrero Mercedes, Basaraba Randall J, Crick Dean C, Spencer John S, Lenaerts Anne J

Abstract excerpt

A unique hallmark of tuberculosis is the granulomatous lesions formed in the lung. Granulomas can be heterogeneous in nature and can develop a necrotic, hypoxic core which is surrounded by an acellular, fibrotic rim. Studying bacilli in this in vivo microenvironment is problematic as Mycobacterium tuberculosis can change its phenotype and also become acid-fast negative. Under in vitro models of differing...

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PMID: 20559431
DOI: 10.1371/journal.pone.0011108
PMCID: PMC2885421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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