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Detecting Phenotypically Resistant Mycobacterium tuberculosis Using Wavelength Modulated Raman Spectroscopy.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Baron Vincent O, Chen Mingzhou, Clark Simon O, Williams Ann, Dholakia Kishan, Gillespie Stephen H

Abstract excerpt

Raman spectroscopy is a non-destructive and label-free technique. Wavelength modulated Raman (WMR) spectroscopy was applied to investigate Mycobacterium tuberculosis cell state, lipid rich (LR) and lipid poor (LP). Compared to LP cells, LR cells can be up to 40 times more resistant to key antibiotic regimens. Using this methodology single lipid rich (LR) from lipid poor (LP) bacteria can be differentiated with...

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Identifiers

PMID: 29322457
DOI: 10.1007/978-1-4939-7638-6_4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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