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Acid-Fast Positive and Acid-Fast NegativeMycobacterium tuberculosis: The Koch Paradox

10 Mar 2017

Abstract excerpt

Acid-fast (AF) staining, also known as Ziehl-Neelsen stain microscopic detection, developed over a century ago, is even today the most widely used diagnostic method for tuberculosis. Herein we present a short historical review of the evolution of AF staining methods and discuss Koch's paradox, in which non-AF tubercle bacilli can be detected in tuberculosis patients or in experimentally infected animals. The...

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PMID: 28337966
DOI: 10.1128/microbiolspec.tbtb2-0003-2015

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