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Accelerated Detection ofMycobacterium tuberculosisGenes Essential for Bacterial Survival in Guinea Pigs, Compared with Mice

3 May 2007

Abstract excerpt

BACKGROUND: Mouse and guinea pig models have been used to identify Mycobacterium tuberculosis mutants attenuated for survival. However, unlike mice, M. tuberculosis-infected guinea pigs form caseating granulomas, which may simulate human disease more closely. METHODS: We used designer arrays for defined mutant analysis, a high-throughput subtractive competition assay, for genotypically defined M. tuberculosis...

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PMID: 17471433
DOI: 10.1086/517526

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