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Article

The epigenetic trans-silencing effect in Drosophila involves maternally-transmitted small RNAs whose production depends on the piRNA pathway and HP1.

PloS one - 14 Jun 2010

Todeschini Anne-Laure, Teysset Laure, Delmarre Valérie, Ronsseray Stéphane

Abstract excerpt

BACKGROUND: The study of P transposable element repression in Drosophila melanogaster led to the discovery of the Trans-Silencing Effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequences, "TAS") has the capacity to repress in trans, in the female germline, a homologous P-lacZ transgene located in euchromatin. Phenotypic...

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Identifiers

PMID: 20559422
DOI: 10.1371/journal.pone.0011032
PMCID: PMC2885412

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