Article
Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation.
PLoS genetics - 1 Sept 2007
Josse Thibaut, Teysset Laure, Todeschini Anne-Laure, Sidor Clara M, Anxolabéhère Dominique, Ronsseray Stéphane
Abstract excerpt
The study of P-element repression in Drosophila melanogaster led to the discovery of the telomeric Trans-Silencing Effect (TSE), a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin (Telomeric Associated Sequence or TAS) has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. TSE shows variegation...
Topics
- Animals
- Chromobox Protein Homolog 5
- DNA Transposable Elements
- Drosophila Proteins
- Drosophila melanogaster
- Epigenesis, Genetic
- Female
- Gene Silencing
- Heterochromatin
- Mutation
- RNA