Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons.

doi:10.1093/nar/gkr552

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Article

Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons.

Nucleic acids research - 1 Nov 2011

Shpiz Sergey, Olovnikov Ivan, Sergeeva Anna, Lavrov Sergey, Abramov Yuri, Savitsky Mikhail, Kalmykova Alla

Abstract excerpt

In the Drosophila germline, retrotransposons are silenced by the PIWI-interacting RNA (piRNA) pathway. Telomeric retroelements HeT-A, TART and TAHRE, which are involved in telomere maintenance in Drosophila, are also the targets of piRNA-mediated silencing. We have demonstrated that expression of reporter genes driven by the HeT-A promoter is under the control of the piRNA silencing pathway independent of the...

Topics

Animals
Drosophila
Female
Gene Silencing
Genes, Reporter
Mutation
Ovary
RNA, Small Interfering
Retroelements
Telomere
Transcription, Genetic
Up-Regulation

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Identifiers

PMID: 21764773
DOI: 10.1093/nar/gkr552
PMCID: PMC3203600

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