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Article

Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons.

Nucleic acids research - 1 Nov 2011

Shpiz Sergey, Olovnikov Ivan, Sergeeva Anna, Lavrov Sergey, Abramov Yuri, Savitsky Mikhail, Kalmykova Alla

Abstract excerpt

In the Drosophila germline, retrotransposons are silenced by the PIWI-interacting RNA (piRNA) pathway. Telomeric retroelements HeT-A, TART and TAHRE, which are involved in telomere maintenance in Drosophila, are also the targets of piRNA-mediated silencing. We have demonstrated that expression of reporter genes driven by the HeT-A promoter is under the control of the piRNA silencing pathway independent of the...

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Identifiers

PMID: 21764773
DOI: 10.1093/nar/gkr552
PMCID: PMC3203600

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