Article
Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.
Genes & development - 15 Nov 2010
Haase Astrid D, Fenoglio Silvia, Muerdter Felix, Guzzardo Paloma M, Czech Benjamin, Pappin Darryl J, Chen Caifu, Gordon Assaf, Hannon Gregory J
Abstract excerpt
Combining RNAi in cultured cells and analysis of mutant animals, we probed the roles of known Piwi-interacting RNA (piRNA) pathway components in the initiation and effector phases of transposon silencing. Squash associated physically with Piwi, and reductions in its expression led to modest transposon derepression without effects on piRNAs, consistent with an effector role. Alterations in Zucchini or Armitage...
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