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Article

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.

Cell cycle (Georgetown, Tex.) - 15 Sept 2013

Zalmas Lykourgos-Panagiotis, Coutts Amanda S, Helleday Thomas, La Thangue Nicholas B

Abstract excerpt

The cellular response to DNA damage, mediated by the DNA repair process, is essential in maintaining the integrity and stability of the genome. E2F-7 is an atypical member of the E2F family with a role in negatively regulating transcription and cell cycle progression under DNA damage. Surprisingly, we found that E2F-7 makes a transcription-independent contribution to the DNA repair process, which involves E2F-7...

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Identifiers

PMID: 23974101
DOI: 10.4161/cc.26078
PMCID: PMC3875678

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