Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

14-3-3 proteins integrate E2F activity with the DNA damage response.

The EMBO journal - 8 Mar 2006

Milton Alasdair H, Khaire Nandkumar, Ingram Laura, O'Donnell Amanda J, La Thangue Nicholas B

Abstract excerpt

The E2F family is composed of at least eight E2F and two DP subunits, which in cells exist as E2F/DP heterodimers that bind to and regulate E2F target genes. While DP-1 is an essential and widespread component of E2F, much less is known about the DP-3 subunit, which exists as a number of distinct protein isoforms that differ in several respects including the presence of a nuclear localisation signal (NLS). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Apoptotic Protease-Activating Factor 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COS Cells

Share to E2F1 Transcription Factor

Share to Genes, Tumor Suppressor

Share to Nuclear Localization Signals

Share to Tumor Protein p73

Source

Open in PubMed Open full text

Identifiers

PMID: 16482218
DOI: 10.1038/sj.emboj.7600999
PMCID: PMC1409719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

14-3-3 proteins integrate E2F activity with the DNA damage response.PMID 16482218Read ↗

E2F3 Is a Mediator of DNA Damage-Induced ApoptosisSemantic proximity Read ↗

E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.Semantic proximity Read ↗

The E2F family: specific functions and overlapping interests.Semantic proximity Read ↗

E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read ↗

The E2F transcription factor 2: What do we know?Semantic proximity Read ↗

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Semantic proximity Read ↗

The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damageSemantic proximity Read ↗

Role of E2F in cell cycle control and cancerSemantic proximity Read ↗

The genetics of the E2F family of transcription factors: shared functions and unique roles.Semantic proximity Read ↗

E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains.Semantic proximity Read ↗

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA DamageSemantic proximity Read ↗

Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.