Article
Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.
PloS one - 1 Jan 2014
Pearson-Fuhrhop Kristin M, Dunn Erin C, Mortero Sarah, Devan William J, Falcone Guido J, Lee Phil, Holmes Avram J, Hollinshead Marisa O, Roffman Joshua L, Smoller Jordan W, Rosand Jonathan, Cramer Steven C
Abstract excerpt
BACKGROUND: Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the pathophysiology of depression, evidence linking dopamine-related genes to depression has been mixed. The current study sought to address this knowledge-gap by examining whether the combined effect of...
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