Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.

PloS one - 1 Jan 2014

Wutthisathapornchai Apilak, Vongpipatana Tuangtong, Muangsawat Sureeporn, Boonsaen Thirajit, MacDonald Michael J, Jitrapakdee Sarawut

Abstract excerpt

Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the glucose-mediated transcriptional regulation of the PC gene. Incubation of the rat insulin cell line INS-1 832/13 with glucose resulted in a 2-fold increase in PC mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucose

Share to Insulinoma

Share to Pancreatic Neoplasms

Share to Response Elements

Share to RNA Interference

Share to Upstream Stimulatory Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25054881
DOI: 10.1371/journal.pone.0102730
PMCID: PMC4108332

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.PMID 25054881Read ↗

Involvement of specific proteins (Sp1/Sp3) and nuclear factor Y in basal transcription of the distal promoter of the rat pyruvate carboxylase gene in beta-cells.Semantic proximity Read ↗

Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes.Semantic proximity Read ↗

An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression.Semantic proximity Read ↗

Spot 14 protein interacts and co-operates with chicken ovalbumin upstream promoter-transcription factor 1 in the transcription of the L-type pyruvate kinase gene through a specificity protein 1 (Sp1) binding site.Semantic proximity Read ↗

MECHANISMS BY WHICH CARBOHYDRATES REGULATE EXPRESSION OF GENES FOR GLYCOLYTIC AND LIPOGENIC ENZYMESSemantic proximity Read ↗

Upstream stimulatory factor proteins are major components of the glucose response complex of the L-type pyruvate kinase gene promoter.Semantic proximity Read ↗

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β CellsSemantic proximity Read ↗

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.Semantic proximity Read ↗

Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolismSemantic proximity Read ↗

Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor.Semantic proximity Read ↗

Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene ExpressionSemantic proximity Read ↗

Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.