Article
SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver.
The Journal of biological chemistry - 9 Apr 2004
Chakravarty Kaushik, Wu Shwu-Yuan, Chiang Cheng-Ming, Samols David, Hanson Richard W
Abstract excerpt
The sterol regulatory element-binding protein-1c (SREBP-1c), as well as SREBP-1a and SREBP-2, inhibit transcription of the gene encoding the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C). There are two SREBP regulatory elements (SREs) in the PEPCK-C gene promoter (-322 to -313 and -590 to -581). The SRE at -590 overlaps an Sp1 site on the opposite strand of the DNA. These SREs bound SREBP-1a...
Topics
- Animals
- Binding Sites
- Binding, Competitive
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- Chromatin
- Cyclic AMP-Dependent Protein Kinases
- DNA, Complementary
- DNA-Binding Proteins
- Dose-Response Relationship, Drug