Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factors.

doi:10.1128/mcb.14.11.7124-7133.1994

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Article

Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factors.

Molecular and cellular biology - 1 Nov 1994

Yanuka-Kashles O, Cohen H, Trus M, Aran A, Benvenisty N, Reshef L

Abstract excerpt

To study the transcriptional regulation of the liver gluconeogenic phenotype, the underdifferentiated mouse Hepa-1c1c7 (Hepa) hepatoma cell line was used. These cells mimicked the fetal liver by appreciably expressing the alpha-fetoprotein and albumin genes but not the phosphoenolpyruvate carboxykinase (PEPCK) gene. Unlike the fetal liver, however, Hepa cells failed to express the early-expressed factors...

Topics

Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Cell Differentiation
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 1-beta
Hepatocyte Nuclear Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms, Experimental

Mice

Nuclear Proteins

Phenotype

Phosphoenolpyruvate Carboxykinase (GTP)

Phosphoproteins

Promoter Regions, Genetic

Rats

Transcription Factors

Source

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Identifiers

PMID: 7935427
DOI: 10.1128/mcb.14.11.7124-7133.1994
PMCID: PMC359246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7935427-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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