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Article

Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus.

Science advances - 27 Jan 2023

Shirogane Yuta, Harada Hidetaka, Hirai Yuichi, Takemoto Ryuichi, Suzuki Tateki, Hashiguchi Takao, Yanagi Yusuke

Abstract excerpt

Measles virus (MeV), which is usually non-neurotropic, sometimes persists in the brain and causes subacute sclerosing panencephalitis (SSPE) several years after acute infection, serving as a model for persistent viral infections. The persisting MeVs have hyperfusogenic mutant fusion (F) proteins that likely enable cell-cell fusion at synapses and "en bloc transmission" between neurons. We here show that during...

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Identifiers

PMID: 36706187
DOI: 10.1126/sciadv.adf3731
PMCID: PMC9882980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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