Article
Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis.
Viruses - 2 Jul 2022
Hollidge Bradley S, Salzano Mary-Virginia, Ibrahim John M, Fraser Jonathan W, Wagner Valentina, Leitner Nicole E, Weiss Susan R, Weber Friedemann, González-Scarano Francisco, Soldan Samantha S
Abstract excerpt
La Crosse virus (LACV) is a major cause of pediatric encephalitis and aseptic meningitis in the Midwestern, Mid-Atlantic, and Southern United States, where it is an emerging pathogen. The LACV Gc glycoprotein plays a critical role in the neuropathogenesis of LACV encephalitis as the putative virus attachment protein. Previously, we identified and experimentally confirmed the location of the LACV fusion peptide...
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