Article
Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22.
Cancer research - 1 Jul 2010
Gray-McGuire Courtney, Guda Kishore, Adrianto Indra, Lin Chee Paul, Natale Leanna, Potter John D, Newcomb Polly, Poole Elizabeth M, Ulrich Cornelia M, Lindor Noralane, Goode Ellen L, Fridley Brooke L, Jenkins Robert, Le Marchand Loic, Casey Graham, Haile Robert, Hopper John, Jenkins Mark, Young Joanne, Buchanan Daniel, Gallinger Steve, Adams Mark, Lewis Susan, Willis Joseph, Elston Robert, Markowitz Sanford D, Wiesner Georgia L
Abstract excerpt
Genetic risk factors are important contributors to the development of colorectal cancer. Following the definition of a linkage signal at 9q22-31, we fine mapped this region in an independent collection of colon cancer families. We used a custom array of single-nucleotide polymorphisms (SNP) densely spaced across the candidate region, performing both single-SNP and moving-window association analyses to identify a...
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