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Article

A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number.

Laboratory investigation; a journal of technical methods and pathology - 1 Sept 2010

Astolfi Annalisa, Nannini Margherita, Pantaleo Maria Abbondanza, Di Battista Monica, Heinrich Michael C, Santini Donatella, Catena Fausto, Corless Christopher L, Maleddu Alessandra, Saponara Maristella, Lolli Cristian, Di Scioscio Valerio, Formica Serena, Biasco Guido

Abstract excerpt

In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. We report the first...

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Source

Identifiers

PMID: 20548289
DOI: 10.1038/labinvest.2010.110

Genes

RTN1
DAAM1
DACT1
KIT
KRAS
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20548289-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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