Article
Genetic aberrations of gastrointestinal stromal tumors.
Cancer - 1 Oct 2008
Yang Jilong, Du Xiaoling, Lazar Alexander J F, Pollock Raphael, Hunt Kelly, Chen Kexin, Hao Xishan, Trent Jonathan, Zhang Wei
Abstract excerpt
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm in the gastrointestinal tract and is associated with mutations of the KIT or PDGFRA gene. In addition, other genetic events are believed to be involved in GIST tumorigenesis. Cytogenetic aberrations associated with these tumors thus far described include loss of 1p, 13q, 14q, or 15q, loss of heterozygosity of 22q, numeric chromosomal...
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