Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors

Abstract excerpt

BACKGROUND: Gastrointestinal stromal tumors (GISTs) historically were grouped with leiomyosarcomas (LMSs) based on their morphologic similarities; however, recently, GIST was established unequivocally as a distinct type of sarcoma based on its molecular features and response to imatinib treatment. METHODS: To gain further insight into the genomic differences between GISTs and LMSs, the authors mapped gene copy...

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