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Article

High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors.

Genes, chromosomes & cancer - 1 Oct 2009

Belinsky Martin G, Skorobogatko Yuliya V, Rink Lori, Pei Jianming, Cai Kathy Q, Vanderveer Lisa A, Riddell David, Merkel Erin, Tarn Chi, Eisenberg Burton L, von Mehren Margaret, Testa Joseph R, Godwin Andrew K

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) generally harbor activating mutations in KIT or platelet-derived growth facter receptor (PDGFRA). Mutations in these receptor tyrosine kinases lead to dysregulation of downstream signaling pathways that contribute to GIST pathogenesis. GISTs with KIT or PDGFRA mutations also undergo secondary cytogenetic alterations that may indicate the involvement of additional genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19585585
DOI: 10.1002/gcc.20689
PMCID: PMC2830286

Genes

KIT
PDGFRA
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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