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Article

Structure function analysis of benzalacetone synthase from Rheum palmatum.

Bioorganic & medicinal chemistry letters - 1 Jun 2007

Abe Tsuyoshi, Morita Hiroyuki, Noma Hisashi, Kohno Toshiyuki, Noguchi Hiroshi, Abe Ikuro

Abstract excerpt

Benzalacetone synthase (BAS) is a plant-specific chalcone synthase (CHS) superfamily type III polyketide synthase (PKS) that catalyzes a one-step decarboxylative condensation of 4-coumaroyl-CoA with malonyl-CoA. The diketide forming activity of Rheum palmatum BAS is attributed to the characteristic substitution of the conserved active-site Phe215 with Leu (numbering in Medicago sativa CHS). To further understand...

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PMID: 17383877
DOI: 10.1016/j.bmcl.2007.03.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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