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Article

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

Nature - 13 May 2012

Ngaki Micheline N, Louie Gordon V, Philippe Ryan N, Manning Gerard, Pojer Florence, Bowman Marianne E, Li Ling, Larsen Elise, Wurtele Eve Syrkin, Noel Joseph P

Abstract excerpt

Specialized metabolic enzymes biosynthesize chemicals of ecological importance, often sharing a pedigree with primary metabolic enzymes. However, the lineage of the enzyme chalcone isomerase (CHI) remained unknown. In vascular plants, CHI-catalysed conversion of chalcones to chiral (S)-flavanones is a committed step in the production of plant flavonoids, compounds that contribute to attraction, defence and...

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Identifiers

PMID: 22622584
DOI: 10.1038/nature11009
PMCID: PMC3880581

Genes

FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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