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Article

Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2018

Ban Zhaonan, Qin Hao, Mitchell Andrew J, Liu Baoxiu, Zhang Fengxia, Weng Jing-Ke, Dixon Richard A, Wang Guodong

Abstract excerpt

Xanthohumol (XN) and demethylxanthohumol (DMX) are specialized prenylated chalconoids with multiple pharmaceutical applications that accumulate to high levels in the glandular trichomes of hops (Humulus lupulus L.). Although all structural enzymes in the XN pathway have been functionally identified, biochemical mechanisms underlying highly efficient production of XN have not been fully resolved. In this study, we...

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PMID: 29760092
DOI: 10.1073/pnas.1802223115
PMCID: PMC5984530

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