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Article

Predicting unobserved phenotypes for complex traits from whole-genome SNP data.

PLoS genetics - 1 Oct 2008

Lee Sang Hong, van der Werf Julius H J, Hayes Ben J, Goddard Michael E, Visscher Peter M

Abstract excerpt

Genome-wide association studies (GWAS) for quantitative traits and disease in humans and other species have shown that there are many loci that contribute to the observed resemblance between relatives. GWAS to date have mostly focussed on discovery of genes or regulatory regions habouring causative polymorphisms, using single SNP analyses and setting stringent type-I error rates. Genome-wide marker data can also...

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PMID: 18949033
DOI: 10.1371/journal.pgen.1000231
PMCID: PMC2565502

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