Article
Effects of kinship correction on inflation of genetic interaction statistics in commonly used mouse populations.
G3 (Bethesda, Md.) - 14 Jul 2021
Tyler Anna L, El Kassaby Baha, Kolishovski Georgi, Emerson Jake, Wells Ann E, Mahoney J Matthew, Carter Gregory W
Abstract excerpt
It is well understood that variation in relatedness among individuals, or kinship, can lead to false genetic associations. Multiple methods have been developed to adjust for kinship while maintaining power to detect true associations. However, relatively unstudied are the effects of kinship on genetic interaction test statistics. Here, we performed a survey of kinship effects on studies of six commonly used mouse...
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