Article
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2010
Lee Suk Hyung, Yun Sohyun, Piao Zheng-Hao, Jeong Mira, Kim Dong Oh, Jung Haiyoung, Lee Jiwon, Kim Mi Jeong, Kim Mi Sun, Chung Jin Woong, Kim Tae-Don, Yoon Suk Ran, Greenberg Philip D, Choi Inpyo
Abstract excerpt
NK cells are capable of killing virus-infected or tumor cells and producing IFN-gamma. Resting NK cells, however, have only minimal cytolytic activity and secrete a low level of IFN-gamma. The cytokine IL-15 can promote the expression of effector functions by resting NK cells. In this study, we demonstrate that suppressor of cytokine signaling 2 (SOCS2) has a novel role in IL-15-primed human NK cell function....
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