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Article

Monoclonal antibodies against nucleophosmin mutants: potentials for the detection of acute myeloid leukemia.

International journal of medical sciences - 1 Jan 2011

Tan Shi, Zhang Ling, Zhong Xiao-Ming, Yang Zai-Lin, Zhao Liu-Yang, Gao Yu-Jie, Shao Hui-Yuan, Qin Feng-Xian, Chen Xian-Chun, Zhang Hui-Juan, Chen Hui, Wang Li

Abstract excerpt

Nucleophosmin (NPM1) gene mutations resulting in cytoplasmic delocalization of Nucleophosmin (NPMc+) are the most common genetic alteration in acute myeloid leukemia (AML). Here, we attempted to prepare monoclonal antibodies (mAbs) against NPM1 mutation A (NPM-mA) and investigated the mAbs' clinical utility in immunohistochemical detection of NPMc+AML. The pET-32a-NPM-mA vector with the whole open reading frame...

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Share to Antibodies, Monoclonal
Share to Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred BALB C

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Share to Nucleophosmin

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Source

Open in PubMed Open full text

Identifiers

PMID: 21611112
DOI: 10.7150/ijms.8.309
PMCID: PMC3100738

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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