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Article

The role of mitochondrial ATP synthase in cancer.

Biological chemistry - 25 Oct 2020

Galber Chiara, Acosta Manuel Jesus, Minervini Giovanni, Giorgio Valentina

Abstract excerpt

The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner mitochondrial membrane which is essential for oxidative phosphorylation under physiological conditions. In this review, we analyse the enzyme functions involved in cancer progression by dissecting specific conditions in which ATP synthase contributes to cancer development or metastasis. Moreover, we propose the role of ATP...

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PMID: 32769215
DOI: 10.1515/hsz-2020-0157

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