Article

IF1 Protein Controls Aging Rate

2021-11-09

Abstract excerpt

<h4>ABSTRACT</h4> IF1 protein inhibits F 1 F 0 ATP hydrolysis (and not F 1 F 0 ATP synthesis). Across investigated species more IF1 protein, and less F 1 F 0 ATP hydrolysis, correlates with greater maximal lifespan. Increased IF1 protein, and decreased F 1 F 0 ATP hydrolysis, safely reduces a biomarker of aging in mice. Body temperature decrease, in mice administered with a small molecule drug that select...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 952b25dc-e613-5d66-94e8-33fe0e2053bb
DOI: 10.1101/2021.10.28.466310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IF1 Protein Controls Aging RateDOI 10.1101/2021.10.28.466310Read

Thermodynamics and information in aging: why aging is not a mystery and how we will be able to make rational interventions.Semantic proximity Read

Systems biology of aging.Semantic proximity Read

Thermal Adaptations in Animals: Genes, Development, and Evolution.Semantic proximity Read

Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.Semantic proximity Read

Thermodynamics--old laws in medicine and complex disease.Semantic proximity Read

Puzzles in modern biology. III.Two kinds of causality in age-related diseaseSemantic proximity Read

Mammal Aging is Controlled by an Evolvability-Based Adaptive Program.Semantic proximity Read

Brief Report: An Evolutionary Basis to Cancer GrowthSemantic proximity Read

Molecular Variation in Thermoregulatory Adaptation in Rodents.Semantic proximity Read

A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of agingSemantic proximity Read

The African Turquoise Killifish: A Model for Exploring Vertebrate Aging and Diseases in the Fast Lane.Semantic proximity Read

Cell size and cancer: a new solution to Peto's paradox?Semantic proximity Read