Article
MICU1 drives glycolysis and chemoresistance in ovarian cancer.
Nature communications - 22 May 2017
Chakraborty Prabir K, Mustafi Soumyajit Banerjee, Xiong Xunhao, Dwivedi Shailendra Kumar Dhar, Nesin Vasyl, Saha Sounik, Zhang Min, Dhanasekaran Danny, Jayaraman Muralidharan, Mannel Robert, Moore Kathleen, McMeekin Scott, Yang Da, Zuna Rosemary, Ding Kai, Tsiokas Leonidas, Bhattacharya Resham, Mukherjee Priyabrata
Abstract excerpt
Cancer cells actively promote aerobic glycolysis to sustain their metabolic requirements through mechanisms not always clear. Here, we demonstrate that the gatekeeper of mitochondrial Ca2+ uptake, Mitochondrial Calcium Uptake 1 (MICU1/CBARA1) drives aerobic glycolysis in ovarian cancer. We show that MICU1 is overexpressed in a panel of ovarian cancer cell lines and that MICU1 overexpression correlates with poor...
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