Article
A mutation in the Kit gene leads to novel gonadal phenotypes in both heterozygous and homozygous mice.
Hereditas - 1 Apr 2010
Wu B J, Yin L J, Yin H P, Ying X S, Yang W W, Zeng Y M, Zhu J, Kang X D, Liu G J, Yu L P, Gu M E, Wu P L
Abstract excerpt
The direct sequencing of the Kit cDNA obtained from mutant mice was used to reveal the molecular nature of the W(-3Bao) ENU-induced mutation. There was a T to A transversion at the 441st nucleotide in the W(-3Bao) open reading frame (ORF), which introduced a pre-mature termination codon at residue 147. The gross embryonic development, hematopoiesis and spermatogenesis were examined in the mutant mice. There was...
Topics
- Animals
- Mice
- Mutation
- Phenotype
- Proto-Oncogene Proteins c-kit