Article
A mutation in the Kit gene leads to novel gonadal phenotypes in both heterozygous and homozygous mice.
Hereditas - 1 Apr 2010
Wu B J, Yin L J, Yin H P, Ying X S, Yang W W, Zeng Y M, Zhu J, Kang X D, Liu G J, Yu L P, Gu M E, Wu P L
Abstract excerpt
The direct sequencing of the Kit cDNA obtained from mutant mice was used to reveal the molecular nature of the W(-3Bao) ENU-induced mutation. There was a T to A transversion at the 441st nucleotide in the W(-3Bao) open reading frame (ORF), which introduced a pre-mature termination codon at residue 147. The gross embryonic development, hematopoiesis and spermatogenesis were examined in the mutant mice. There was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.