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Article

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development.

The Journal of experimental medicine - 15 Mar 2004

Agosti Valter, Corbacioglu Selim, Ehlers Imke, Waskow Claudia, Sommer Gunhild, Berrozpe Georgina, Kissel Holger, Tucker Christine M, Manova Katia, Moore Malcolm A S, Rodewald Hans-Reimer, Besmer Peter

Abstract excerpt

The Kit receptor functions in hematopoiesis, lymphocyte development, gastrointestinal tract motility, melanogenesis, and gametogenesis. To investigate the roles of different Kit signaling pathways in vivo, we have generated knock-in mice in which docking sites for PI 3-kinase (KitY719) or Src kinase (KitY567) have been mutated. Whereas steady-state hematopoiesis is normal in KitY719F/Y719F and KitY567F/Y567F...

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Identifiers

PMID: 15024050
DOI: 10.1084/jem.20031983
PMCID: PMC2212729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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