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A mutation of cysteine 46 in IKK-β promotes mPGES-1 and caveolin-1 expression to exacerbate osteoclast differentiation and osteolysis.

Biochemical pharmacology - 1 Feb 2020

Zou Binhua, Zhang Yueyang, Li Ting, Liu Juan, Deng Wende, Tan Yanhui, Yang Qin, Ding Zongbao, Liao Kangsheng, Xu Jialan, Pan Hudan, Li Xiaojuan, Liu Liang

Abstract excerpt

IKK-β is indispensable for inflammatory osteolysis, the functional residues of IKK-β are therapeutic drug targets for developing inhibitors to treat multiple diseases now. Thus it remains appealing to find the new residues of IKK-β to influence osteoclasts for alleviating bone loss diseases such as rheumatoid arthritis (RA). By employing IKK-β cysteine 46-A transgenic (IKK-βC46A) mice, we found that mutation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31843541
DOI: 10.1016/j.bcp.2019.113762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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