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Article

TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesis.

The Journal of biological chemistry - 10 Aug 2001

Abu-Amer Y, Dowdy S F, Ross F P, Clohisy J C, Teitelbaum S L

Abstract excerpt

In most circumstances, NF-kappaB, which is essential for osteoclastogenesis, is activated following serine 32/36 phosphorylation of its cytosolic inhibitory protein, IkappaBalpha. In contrast to other cell types, IkappaBalpha, in bone marrow macrophages (BMMs), which are osteoclast precursors, is tyrosine-phosphorylated by c-Src kinase. To address the role of IkappaBalpha phosphorylation in osteoclastogenesis, we...

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Identifiers

PMID: 11408488
DOI: 10.1074/jbc.M104725200

Genes

TAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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