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Article

IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2010

Otero Jesse E, Dai Simon, Alhawagri Muhammad A, Darwech Isra, Abu-Amer Yousef

Abstract excerpt

Monocytes differentiate into osteoclasts through stimulation of receptor activator of NF-kappaB (RANK). Many downstream effectors of RANK play a positive role in osteoclastogenesis, but their relative importance in osteoclast differentiation is unclear. We report the discovery that activation of a single pathway downstream of RANK is sufficient for osteoclast differentiation. In this regard, introduction of...

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Source

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Identifiers

PMID: 20200955
DOI: 10.1002/jbmr.4
PMCID: PMC3153134

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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