Article
A potential role for initiator-tRNA in pre-mRNA splicing regulation.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010
Kamhi Eyal, Raitskin Oleg, Sperling Ruth, Sperling Joseph
Abstract excerpt
The translation initiator-tRNA plays a crucial role in the initiation of protein synthesis in both prokaryotic and eukaryotic cells, by employing specific base pairing between its anticodon triplet CAU and the general initiation codon AUG in the mRNA. Here we show that the initiator-tRNA may also act, in a manner that is independent of its role in protein translation, as a pre-mRNA splicing regulator....
Topics
- Alternative Splicing
- Amino Acids
- Cell Line
- Cell Nucleus
- Codon, Initiator
- Humans
- Methionine
- Models, Biological
- Mutation
- Plasmids
- Protein Biosynthesis
- RNA Precursors
- RNA Splicing
- RNA, Transfer
- Spliceosomes