Article

The 3'tsRNAs are aminoacylated: Implications for their biogenesis

2020-12-16

Abstract excerpt

Emerging evidence indicates that tRNA-derived small RNAs (tsRNAs) are involved in fine-tuning gene expression and become dysregulated in various cancers. We recently showed that the 22nt LeuCAG tsRNA from 3’ end of tRNA Leu is required for efficient translation of a ribosomal protein mRNA and ribosome biogenesis. Inactivation of this tsRNA induced apoptosis in rapidly dividing cells and suppressed the growth of a...

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Literature Corpus work: ee9e8d14-2991-5511-83a5-4871cc288ff0
DOI: 10.1101/2020.12.15.422816

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